SCHEMBL10695903

SCHEMBL10695903

COC(=O)CC(c1ccccc1)C(C#N)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 11/20 0.53
ESR1 P03372 1/20 0.43
ESR2 Q92731 1/20 0.43
ALDH1A1 P00352 2/20 0.42
KMT2A Q03164 2/20 0.41
HTT P42858 1/20 0.40
AKR1C3 P42330 1/20 0.39
AKR1C1 Q04828 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10180840 0.88 KCNA5 (0.43) KCNA5ALDH1A1KMT2AHPGD
SCHEMBL10696020 0.88 KCNA5 (0.46) KCNA5ALDH1A1KMT2AHTTHPGD
SCHEMBL10695685 0.87 KCNA5 (0.45) KCNA5ALDH1A1KMT2AHTTHPGD
SCHEMBL10697424 0.86 KCNA5 (0.44) KCNA5ALDH1A1KMT2AHTTHPGD
SCHEMBL11157075 0.85 TSHR (0.45) KCNA5ESR1ESR2ALDH1A1KMT2A
SCHEMBL11160525 0.85 TSHR (0.46) KCNA5ESR1ESR2ALDH1A1KMT2A
SCHEMBL16398617 0.85 KCNA5 (0.43) KCNA5ALDH1A1
SCHEMBL12473253 0.84 KCNA5 (0.65) KCNA5ALDH1A1KMT2AHPGD
SCHEMBL15959947 0.83 ESR1 (0.44) KCNA5ESR1ESR2ALDH1A1KMT2A
SCHEMBL10179071 0.83 KCNA5 (0.40) KCNA5ALDH1A1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0270830-A1 Method for regulating plant growth using polysubstituted butyric acids, esters and derivatives thereof AMERICAN CYANAMID COMPANY (US) 1988-06-15 EP claimed
US-4224052-A Polysubstituted butanoic acids, esters and derivatives thereof utilizing the same as herbicides AMERICAN CYANAMID COMPANY (US) 1980-09-23 US claimed
US-4383848-A Polysubstituted butanoic acids, esters and derivatives thereof utilizing the same as herbicides AMERICAN CYANAMID COMPANY (US) 1983-05-17 US disclosed
US-4313754-A Polysubstituted butanoic acids, esters and derivatives thereof utilizing the same as herbicides AMERICAN CYANAMID COMPANY (US) 1982-02-02 US disclosed
US-4224052-A Polysubstituted butanoic acids, esters and derivatives thereof utilizing the same as herbicides AMERICAN CYANAMID COMPANY (US) 1980-09-23 US disclosed
EP-0005341-A2 Polysubstituted butanoic acids, esters and derivatives thereof useful as herbicides, Compositions containing them and their use AMERICAN CYANAMID COMPANY (US) 1979-11-14 EP disclosed