SCHEMBL10698010

CC(C)CCC[C@@H](C)[C@H]1C[C@H](O)[C@@]2(C)C3=CC[C@H]4C(C)(C)CCC(OC(=O)c5ccccc5)[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 0.45

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	HMGCR	P04035	2/20	0.45

▸	PRKAG1	P54619	15/20	0.42

▸	PRKAA2	P54646	15/20	0.42

▸	PRKAB1	Q9Y478	15/20	0.42

▸	PTPN1	P18031	1/20	0.39

▸	EBP	Q15125	2/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL10698012	0.88	HMGCR (0.54)	HMGCRPTPN1
SCHEMBL9769592	0.88	HMGCR (0.54)	HMGCRPTPN1
SCHEMBL9769593	0.88	HMGCR (0.54)	HMGCRPTPN1
SCHEMBL9769614	0.82	HMGCR (0.46)	HMGCREBP
SCHEMBL9769594	0.80	HMGCR (0.49)	HMGCRPTPN1
SCHEMBL9769587	0.80	HMGCR (0.49)	HMGCRPTPN1
SCHEMBL10697421	0.78	HMGCR (0.38)	HMGCRPRKAG1PRKAA2PRKAB1PTPN1
SCHEMBL9766817	0.74	HMGCR (0.53)	HMGCRPRKAG1PRKAA2PRKAB1PTPN1
SCHEMBL9766813	0.74	HMGCR (0.53)	HMGCRPRKAG1PRKAA2PRKAB1PTPN1
SCHEMBL9766823	0.73	HMGCR (0.52)	HMGCRPTPN1EBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0276823-A2	14,15-Substituted lanosterols and their use as hypocholesterolemic agents	THE DU PONT MERCK PHARMACEUTICAL COMPANY (US)	1988-08-03	—	—	EP	disclosed