Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRB | O95718 | 6/20 | 0.52 |
| ▸ | ESR1 | P03372 | 16/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.49 |
| ▸ | ESRRG | P62508 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PLD2 | O14939 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
| ▸ | ESRRA | P11474 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696281 | 1.00 | ESRRB (0.52) | ESRRBESR1ESR2ESRRGKDM4E | |
| SCHEMBL11567557 | 0.92 | ESR1 (0.48) | ESRRBESR1ESR2ESRRGKDM4E | |
| SCHEMBL11567221 | 0.92 | ESR1 (0.48) | ESRRBESR1ESR2ESRRGKDM4E | |
| SCHEMBL11565218 | 0.91 | ESR1 (0.49) | ESRRBESR1ESR2ESRRGKDM4E | |
| SCHEMBL11570305 | 0.91 | ESR1 (0.49) | ESRRBESR1ESR2ESRRGKDM4E | |
| SCHEMBL11567007 | 0.89 | ESR1 (0.48) | ESRRBESR1ESR2ESRRGKDM4E | |
| SCHEMBL4543424 | 0.89 | ESR1 (0.59) | ESRRBESR1ESR2ESRRGKDM4E | |
| SCHEMBL10698397 | 0.85 | GBA1 (0.41) | ESRRBESR1ESR2ESRRGMEN1 | |
| SCHEMBL2710225 | 0.83 | CYP2D6 (0.55) | ESRRBESR1ESR2ESRRGKDM4E | |
| SCHEMBL7929087 | 0.83 | CYP2D6 (0.55) | ESRRBESR1ESR2ESRRGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272330-A1 | 1,1,2-TRIARYL-1-BUTENE DERIVATIVES | TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) | 1988-06-29 | — | — | EP | disclosed |