Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699273 | 0.96 | DHODH (0.39) | DHODHMEN1KMT2AJAK2JAK1 | |
| SCHEMBL10700981 | 0.90 | MEN1 (0.37) | DHODHMEN1KMT2AJAK2JAK1 | |
| SCHEMBL10699478 | 0.89 | MEN1 (0.41) | MEN1KMT2AJAK2JAK1TYK2 | |
| SCHEMBL10697969 | 0.89 | MEN1 (0.35) | MEN1KMT2AJAK2JAK1TYK2 | |
| SCHEMBL10698416 | 0.86 | MEN1 (0.37) | DHODHMEN1KMT2AJAK2JAK1 | |
| SCHEMBL10694972 | 0.85 | MEN1 (0.40) | DHODHMEN1KMT2AJAK2JAK1 | |
| SCHEMBL10697536 | 0.85 | MEN1 (0.35) | MEN1KMT2AJAK2JAK1TYK2 | |
| SCHEMBL10701679 | 0.85 | MEN1 (0.41) | MEN1KMT2AJAK2JAK1TYK2 | |
| SCHEMBL10699903 | 0.84 | CYP11B1 (0.47) | MEN1KMT2A | |
| SCHEMBL10697886 | 0.80 | CYP11B1 (0.47) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |