Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flurbiprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 11/20 | 1.00 |
| ▸ | AKR1C2 | P52895 | 11/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | FABP2 | P12104 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | AKR1C4 | P17516 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 1/20 | 1.00 |
| ▸ | HTR2C | P28335 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tarenflurbil SCHEMBL26131 | 1.00 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1PTGS2CYP2C19 | |
| Esflurbiprofen SCHEMBL505817 | 1.00 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1PTGS2CYP2C19 | |
| Tarenflurbil SCHEMBL29350102 | 1.00 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1PTGS2CYP2C19 | |
| Flurbiprofen SCHEMBL8754830 | 1.00 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1PTGS2CYP2C19 | |
| Flurbiprofen SCHEMBL8754978 | 1.00 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1PTGS2CYP2C19 | |
| Flurbiprofen SCHEMBL10029029 | 1.00 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1PTGS2CYP2C19 | |
| Flurbiprofen SCHEMBL2248 | 1.00 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1PTGS2CYP2C19 | |
| Flurbiprofen SCHEMBL8755275 | 1.00 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS1PTGS2CYP2C19 | |
| Flurbiprofen SCHEMBL3519037 | 0.98 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS1PTGS2CYP2C19 | |
| Flurbiprofen SCHEMBL9877586 | 0.98 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS1PTGS2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106535819-A | Delivery system for positioning and affixing surgical mesh or surgical buttress covering surgical margin | 灵敏生物公司 | 2017-03-22 | — | — | CN | disclosed |
| US-20160175436-A1 | COMPOSITIONS AND METHODS FOR MUCOSITIS AND ONCOLOGY THERAPIES | VICUS THERAPEUTICS LLC (US) | 2016-06-23 | — | — | US | disclosed |
| EP-2972257-A1 | IMPROVED TECHNIQUES, SYSTEMS AND MACHINE READABLE PROGRAMS FOR MAGNETIC RESONANCE | Millikelvin Technologies Llc (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014144083-A9 | IMPROVED TECHNIQUES, SYSTEMS AND MACHINE READABLE PROGRAMS FOR MAGNETIC RESONANCE | MILLIKELVIN TECHNOLOGIES LLC (US) | 2015-04-23 | — | — | WO | disclosed |
| WO-2014152024-A2 | IMPROVED TECHNIQUES, SYSTEMS AND MACHINE READABLE PROGRAMS FOR MAGNETIC RESONANCE | MILLIKELVIN TECHNOLOGIES LLC (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014152042-A2 | IMPROVED TECHNIQUES, SYSTEMS AND MACHINE READABLE PROGRAMS FOR MAGNETIC RESONANCE | MILLIKELVIN TECHNOLOGIES LLC (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014144083-A1 | IMPROVED TECHNIQUES, SYSTEMS AND MACHINE READABLE PROGRAMS FOR MAGNETIC RESONANCE | MILLIKELVIN TECHNOLOGIES LLC (US) | 2014-09-18 | — | — | WO | disclosed |
| EP-2271991-A1 | DATA COLLECTION AND TARGETED ADVERTISING SYSTEMS AND METHODS | Intertrust Technologies Corporation (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009134432-A1 | DATA COLLECTION AND TARGETED ADVERTISING SYSTEMS AND METHODS | INTERTRUST TECHNOLOGIES CORPORATION (US) | 2009-11-05 | — | — | WO | disclosed |
| EP-2054052-A1 | DRUG COMBINATION PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USING THEM | Vicus Therapeutics SPE 1, LLC (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-0805684-A2 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1997-11-12 | — | — | EP | disclosed |
| WO-1996022780-A1 | METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 1996-08-01 | — | — | WO | disclosed |
| WO-1995033492-A9 | METHODS AND COMPOSITIONS FOR MODULATION OF WOUND HEALING | — | 1996-02-29 | — | — | WO | disclosed |
| WO-1995033492-A1 | METHODS AND COMPOSITIONS FOR MODULATION OF WOUND HEALING | HOUSTON BIOTECHNOLOGY INCORPORATED (US) | 1995-12-14 | — | — | WO | disclosed |
| EP-0215423-B1 | TRANSDERMALLY RESORBABLE AQUEOUS COMPOSITIONS OF ARYLPROPIONIC-ACID DERIVATIVES AND PROCESS FOR THEIR PREPARATION | Dolorgiet GmbH & Co. KG (DE) | 1991-05-08 | — | — | EP | disclosed |
| US-4849418-A | Transdermally absorbable water-containing preparations of arylpropionic acid derivatives and process for preparing same | DOLORGIET BETEILIGUNGS-GMBH (DE) | 1989-07-18 | — | — | US | disclosed |
| EP-0215423-A2 | Transdermally resorbable aqueous compositions of arylpropionic-acid derivatives and process for their preparation | Dolorgiet GmbH & Co. KG (DE) | 1987-03-25 | — | — | EP | disclosed |
| US-4292319-A | MIXTURE WITH AN ANTIULCER AGENT | BOEHRINGER INGELHEIM GMBH (DE) | 1981-09-29 | — | — | US | disclosed |
| US-4256747-A | ANTIINFLAMMATORY AGENTS, PYRIDO/2,3B//1,4/BENZODIAZEPIN-6-ONES | BOEHRINGER INGELHEIM GMBH (DE) | 1981-03-17 | — | — | US | disclosed |
| US-4154833-A | INDOMETHACIN (1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID) WITH PIRENZEPINE (5,11-DIHYDRO-11-((4-METHYL-1-PIPERAZINYL)-ACETYL)-6H-PYRIDO(2,3 -B)(1,4)BENZODIAZEPIN-6-ONE) | BOEHRINGER INGELHEIM GMBH (DE) | 1979-05-15 | — | — | US | disclosed |