SCHEMBL10709552

SCHEMBL10709552

C[Si](C)(C)CCP(c1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
ESR1 P03372 2/20 0.31
ESR2 Q92731 2/20 0.31
KDM4E B2RXH2 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10727558 0.98 CYP3A4 (0.35) CYP3A4TDP1ESR1ESR2
Carbon Monoxide SCHEMBL10787646 0.92 CYP3A4 (0.31) CYP3A4TDP1
Carbon Monoxide SCHEMBL11047916 0.92 CYP3A4 (0.31) CYP3A4TDP1
Formaldehyde SCHEMBL11044782 0.92 CYP3A4 (0.31) CYP3A4TDP1
Formaldehyde SCHEMBL11042538 0.92 CYP3A4 (0.31) CYP3A4TDP1
Formaldehyde SCHEMBL10730741 0.92 CYP3A4 (0.31) CYP3A4TDP1
Formaldehyde SCHEMBL11044042 0.92 CYP3A4 (0.31) CYP3A4TDP1
Carbon Monoxide SCHEMBL11042533 0.90 CYP3A4 (0.30) CYP3A4TDP1
Carbon Monoxide SCHEMBL11044040 0.90 CYP3A4 (0.30) CYP3A4TDP1
Carbon Monoxide SCHEMBL11044780 0.90 CYP3A4 (0.30) CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0155551-B1 METHOD FOR THE PARTIAL HYDROGENATION OF CONJUGATED DIENES MITSUBISHI KASEI CORPORATION (JP) 1988-07-06 EP disclosed
US-4687874-A Selective hydroformylation process using alkyl diaryl phosphine rhodium carbonyl hydride catalysts EXXON RESEARCH AND ENGINEERING COMPANY (US) 1987-08-18 US disclosed
US-4687866-A Ligand exchange process for producing alkyl diaryl phosphine rhodium carbonyl hydrides EXXON RESEARCH AND ENGINEERING COMPANY (US) 1987-08-18 US disclosed
US-4668809-A ALKYL DIARYLPHOSPHINE RHODIUM CARBONYL HYDRIDES, HYDROFORMYLATION, OLEFINS EXXON RESEARCH AND ENGINEERING (US) 1987-05-26 US disclosed
EP-0071281-B1 HYDROFORMYLATION PROCESS EXXON RESEARCH AND ENGINEERING COMPANY (US) 1986-06-18 EP disclosed
US-4595753-A Nitrogen heterocycle substituted EXXON RESEARCH AND ENGINEERING CO. (US) 1986-06-17 US disclosed
US-4593141-A Aliphatic monoolefins to aldehydes EXXON RESEARCH AND ENGINEERING CO. (US) 1986-06-03 US disclosed
US-4590319-A USING AS CATALYST A COBALT COMPOUND, ORGANOPHOSPHINE COMPOUND, AND ALUMINUM COMPOUND MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JP) 1986-05-20 US disclosed
EP-0159460-A1 A hydroformylation catalyst and process EXXON RESEARCH AND ENGINEERING COMPANY (US) 1985-10-30 EP disclosed
EP-0155551-A1 Method for the partial hydrogenation of conjugated dienes MITSUBISHI KASEI CORPORATION (JP) 1985-09-25 EP disclosed
EP-0024091-B1 HYDROFORMYLATION PROCESS AND NOVEL TRANSITION METAL CATALYSTS EXXON RESEARCH AND ENGINEERING COMPANY (US) 1985-04-03 EP disclosed
US-4480137-A ALDEHYDES FROM ALPHA-OLEFINS; HEAT RESISTANCE; CATALYST SELECTIVITY EXXON RESEARCH & ENGINEERING COMPANY (US) 1984-10-30 US disclosed
US-4454353-A Trihydrocarbyl silyl substituted alkyl diaryl phosphine transition metal complexes and their use as homogeneous hydroformylation-aldolization catalysts EXXON RESEARCH AND ENGINEERING CO. (US) 1984-06-12 US disclosed
US-4451673-A REACTING OLEFINS WITH CARBON MONOXIDE AND HYDROGEN TO YIELD ALDEHYDES EXXON RESEARCH AND ENGINEERING CO. (US) 1984-05-29 US disclosed
US-4450299-A ALDEHYDES FROM UNSATURATED ACYCLIC HYDROCARBONS, CARBON MONOXIDE AND HYDROGEN EXXON RESEARCH AND ENGINEERING CO. (US) 1984-05-22 US disclosed
EP-0071281-A2 Hydroformylation process EXXON RESEARCH AND ENGINEERING COMPANY (US) 1983-02-09 EP disclosed
US-4298541-A HYDROFORMYLATION OF ALPHA OLEFINS EXXON RESEARCH & ENGINEERING CO. (US) 1981-11-03 US disclosed
EP-0024091-A4 HYDROFORMYLATION PROCESS AND NOVEL TRANSITION METAL CATALYSTS. EXXON RESEARCH ENGINEERING CO (US) 1981-07-16 EP disclosed
EP-0024091-A1 HYDROFORMYLATION PROCESS AND NOVEL TRANSITION METAL CATALYSTS. EXXON RESEARCH ENGINEERING CO (US) 1981-02-25 EP disclosed
WO-1980001690-A1 CARBONYLATION PROCESS AND NOVEL TRANSITION METAL CATALYSTS EXXON RESEARCH ENGINEERING CO (US) 1980-08-21 WO disclosed