Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 19/20 | 0.75 |
| ▸ | PDE3A | Q14432 | 19/20 | 0.75 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10729985 | 0.86 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL10725801 | 0.84 | PDE3B (0.73) | PDE3BPDE3AHCAR1 | |
| SCHEMBL10727815 | 0.81 | PDE3B (0.68) | PDE3BPDE3A | |
| SCHEMBL10727657 | 0.81 | PDE3B (0.72) | PDE3BPDE3A | |
| SCHEMBL10724775 | 0.81 | PDE3B (0.72) | PDE3BPDE3AHCAR1 | |
| SCHEMBL10724886 | 0.81 | PDE3B (0.68) | PDE3BPDE3A | |
| SCHEMBL10728253 | 0.80 | PDE3B (0.67) | PDE3BPDE3A | |
| SCHEMBL10725998 | 0.80 | PDE3B (0.67) | PDE3BPDE3A | |
| SCHEMBL10728141 | 0.78 | PDE3B (0.64) | PDE3BPDE3A | |
| SCHEMBL10731339 | 0.75 | PDE3B (0.53) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4716170-A | 5-[1H-(5-membered-N-aromatic heteryl)-1-yl]-1,6-naphthyridin-2(1H)-ones and their cardiotonic use | STERLING DRUG INC. (US) | 1987-12-29 | — | — | US | disclosed |
| US-4697021-A | 1,6-dihydro-6-oxo-3-pyridinecarbonitriles, intermediates for cardiotonic agents | STERLING DRUG INC. (US) | 1987-09-29 | — | — | US | disclosed |
| US-4657915-A | INOTROPIC AGENTS | STERLING DRUG INC. (US) | 1987-04-14 | — | — | US | disclosed |
| US-4634772-A | 2-[2-(di-lower-alkylamino)-1-propenyl]-6-methoxy-3-pyridinecarbonitriles, intermediates for cardiotonic agents | STERLING DRUG INC. (US) | 1987-01-06 | — | — | US | disclosed |
| EP-0189853-A2 | 1,6-Naphthyridin-2(1H)-ones having cardiotonic activity and preparation | STERLING DRUG INC. (US) | 1986-08-06 | — | — | EP | disclosed |