Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 10/20 | 1.00 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10726010 | 1.00 | PDE3B (1.00) | PDE3BPDE3ACREBBPMEN1NPC1 | |
| SCHEMBL10760728 | 0.85 | PDE3B (0.73) | PDE3BPDE3ARAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL10759796 | 0.82 | PDE3B (0.69) | PDE3BPDE3ANPC1RAB9AMAPT | |
| SCHEMBL10761737 | 0.80 | PDE3B (0.67) | PDE3BPDE3ANPC1RAB9AMAPT | |
| SCHEMBL10764653 | 0.80 | PDE3B (0.67) | PDE3BPDE3ACREBBPRAB9ASMN1; SMN2 | |
| SCHEMBL10761194 | 0.79 | PDE3B (0.65) | PDE3BPDE3ANPC1RAB9AMAPT | |
| SCHEMBL10765163 | 0.79 | PDE3B (0.65) | PDE3BPDE3ANPC1RAB9AMAPT | |
| SCHEMBL7285568 | 0.79 | PDE3B (0.65) | PDE3BPDE3ANPC1RAB9AMAPT | |
| SCHEMBL10761216 | 0.79 | PDE3B (0.65) | PDE3BPDE3ANPC1RAB9AMAPT | |
| SCHEMBL7284830 | 0.78 | PDE3B (0.66) | PDE3BPDE3AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4656170-A | CARDIOTONIC, HYPOTENSIVE, ANTITHROMBOTIC | WARNER-LAMBERT COMPANY (US) | 1987-04-07 | — | — | US | claimed |
| US-4656170-A | CARDIOTONIC, HYPOTENSIVE, ANTITHROMBOTIC | WARNER-LAMBERT COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| US-4656170-A | CARDIOTONIC, HYPOTENSIVE, ANTITHROMBOTIC | WARNER-LAMBERT COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| US-4656170-A | CARDIOTONIC, HYPOTENSIVE, ANTITHROMBOTIC | WARNER-LAMBERT COMPANY (US) | 1987-04-07 | — | — | US | disclosed |
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |