Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1253725 | 0.80 | ATM (0.55) | POLBMAPTHPGDSMN1; SMN2CYP2C9 | |
| SCHEMBL30572146 | 0.80 | ATM (0.55) | POLBMAPTHPGDSMN1; SMN2CYP2C9 | |
| SCHEMBL1018147 | 0.79 | ATM (0.54) | POLBMAPTHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL14082186 | 0.79 | HPGD (0.71) | POLBMAPTHPGDSMN1; SMN2KMT2A | |
| SCHEMBL1071329 | 0.78 | NTRK1 (0.47) | HPGD | |
| SCHEMBL2119183 | 0.74 | KDM4E (0.44) | POLBMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL30865898 | 0.74 | KDM4E (0.44) | POLBMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL26036542 | 0.74 | NAMPT (0.42) | POLBMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL743611 | 0.72 | HPGD (1.00) | POLBHPGDSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL29687327 | 0.72 | HPGD (1.00) | POLBHPGDSMN1; SMN2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271642-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | Genentech, Inc. (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009126863-A2 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-10-15 | — | — | WO | disclosed |