Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 17/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 17/20 | 0.55 |
| ▸ | KDM4A | O75164 | 3/20 | 0.46 |
| ▸ | KDM4B | O94953 | 3/20 | 0.46 |
| ▸ | KDM5C | P41229 | 3/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10729714 | 0.82 | PDE3B (0.60) | PDE3BPDE3A | |
| SCHEMBL10731339 | 0.82 | PDE3B (0.53) | PDE3BPDE3A | |
| SCHEMBL10727956 | 0.78 | PDE3B (0.49) | PDE3BPDE3A | |
| SCHEMBL10724886 | 0.74 | PDE3B (0.68) | PDE3BPDE3A | |
| SCHEMBL10724674 | 0.74 | PDE3B (0.53) | PDE3BPDE3AKDM4AKDM4BKDM5C | |
| SCHEMBL10727719 | 0.73 | PDE3B (0.56) | PDE3BPDE3A | |
| SCHEMBL7378876 | 0.71 | PDE3B (1.00) | PDE3BPDE3A | |
| SCHEMBL10730080 | 0.71 | PDE3B (0.60) | PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL7383599 | 0.70 | PDE3B (0.97) | PDE3BPDE3A | |
| SCHEMBL10724726 | 0.69 | PDE3B (0.61) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4716170-A | 5-[1H-(5-membered-N-aromatic heteryl)-1-yl]-1,6-naphthyridin-2(1H)-ones and their cardiotonic use | STERLING DRUG INC. (US) | 1987-12-29 | — | — | US | disclosed |
| US-4697021-A | 1,6-dihydro-6-oxo-3-pyridinecarbonitriles, intermediates for cardiotonic agents | STERLING DRUG INC. (US) | 1987-09-29 | — | — | US | disclosed |
| US-4657915-A | INOTROPIC AGENTS | STERLING DRUG INC. (US) | 1987-04-14 | — | — | US | disclosed |
| US-4634772-A | 2-[2-(di-lower-alkylamino)-1-propenyl]-6-methoxy-3-pyridinecarbonitriles, intermediates for cardiotonic agents | STERLING DRUG INC. (US) | 1987-01-06 | — | — | US | disclosed |
| EP-0189853-A2 | 1,6-Naphthyridin-2(1H)-ones having cardiotonic activity and preparation | STERLING DRUG INC. (US) | 1986-08-06 | — | — | EP | disclosed |