Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.52 |
| ▸ | TYK2 | P29597 | 4/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.52 |
| ▸ | JAK1 | P23458 | 2/20 | 0.52 |
| ▸ | BMPR2 | Q13873 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 3/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1074730 | 0.91 | TYK2 (0.60) | JAK2TYK2JAK3JAK1BMPR2 | |
| Trifluoroacetic Acid SCHEMBL1076070 | 0.85 | BMPR2 (0.47) | JAK2TYK2JAK3JAK1BMPR2 | |
| Trifluoroacetic Acid SCHEMBL1072466 | 0.84 | JAK2 (0.66) | JAK2TYK2JAK3JAK1ALK | |
| Trifluoroacetic Acid SCHEMBL1075014 | 0.84 | JAK2 (0.66) | JAK2TYK2JAK3JAK1ALK | |
| Trifluoroacetic Acid SCHEMBL1075155 | 0.84 | JAK2 (0.55) | JAK2TYK2JAK3JAK1FLT3 | |
| Trifluoroacetic Acid SCHEMBL1073013 | 0.83 | JAK2 (0.55) | JAK2TYK2JAK3JAK1FLT3 | |
| Trifluoroacetic Acid SCHEMBL1075017 | 0.80 | ALK (0.37) | JAK2TYK2JAK3JAK1CDK2 | |
| SCHEMBL1082920 | 0.79 | JAK2 (0.42) | JAK2TYK2JAK3JAK1BMPR2 | |
| Hydrochloric Acid SCHEMBL1075957 | 0.78 | BMPR2 (0.51) | JAK2TYK2JAK3JAK1BMPR2 | |
| Trifluoroacetic Acid SCHEMBL1071674 | 0.77 | BMPR2 (0.53) | JAK2TYK2JAK3JAK1BMPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |