Succinic Acid

Succinic Acid

SCHEMBL10732009

O=C(O)CCC(=O)O.O=[N+]([O-])C=C1NCCCN1Cc1ccncc1

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA1 P02708 1/20 0.62
CHRNA3 P32297 1/20 0.62
CHRNA7 P36544 1/20 0.62
SMN1; SMN2 Q16637 3/20 0.54
POLB P06746 3/20 0.35
KDM4E B2RXH2 4/20 0.34
ALDH1A1 P00352 3/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNA4 P43681 1/20 0.34
HDAC1 Q13547 1/20 0.32
TSHR P16473 1/20 0.32
MAPT P10636 1/20 0.32
HTT P42858 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
BCHE P06276 1/20 0.32
ITGB3 P05106 1/20 0.31
ITGA2B P08514 1/20 0.31
SIGMAR1 Q99720 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7993656 0.92 CHRNA1 (0.71) CHRNA1CHRNA3CHRNA7SMN1; SMN2POLB
Hydrochloric Acid SCHEMBL10734627 0.91 CHRNA1 (0.69) CHRNA1CHRNA3CHRNA7SMN1; SMN2POLB
Acetic Acid SCHEMBL10730303 0.89 CHRNA1 (0.62) CHRNA1CHRNA3CHRNA7SMN1; SMN2POLB
SCHEMBL10738351 0.86 SMN1; SMN2 (0.69) CHRNA1CHRNA3CHRNA7SMN1; SMN2POLB
SCHEMBL10738344 0.86 SMN1; SMN2 (0.69) CHRNA1CHRNA3CHRNA7SMN1; SMN2POLB
Hydrochloric Acid SCHEMBL10730736 0.84 SMN1; SMN2 (0.67) CHRNA1CHRNA3CHRNA7SMN1; SMN2POLB
Hydrochloric Acid SCHEMBL10730730 0.84 SMN1; SMN2 (0.67) CHRNA1CHRNA3CHRNA7SMN1; SMN2POLB
SCHEMBL9408645 0.83 CHRNA1 (0.69) CHRNA1CHRNA3CHRNA7SMN1; SMN2POLB
SCHEMBL7981835 0.83 CHRNA1 (0.69) CHRNA1CHRNA3CHRNA7SMN1; SMN2POLB
SCHEMBL10875286 0.83 CHRNA1 (0.65) CHRNA1CHRNA3CHRNA7SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4680294-A Pesticidal novel nitromethylene derivatives NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1987-07-14 US disclosed
US-4647570-A Pesticidal novel nitromethylene derivatives NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1987-03-03 US disclosed