Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.61 |
| ▸ | CNR2 | P34972 | 4/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1074542 | 0.88 | ACKR3 (0.74) | ACKR3CNR2TP53SMN1; SMN2POLB | |
| SCHEMBL1074343 | 0.87 | ACKR3 (0.80) | ACKR3THRBMAPTRXFP1GAA | |
| SCHEMBL1549505 | 0.86 | ACKR3 (0.64) | ACKR3CNR2THRBMAPTRXFP1 | |
| SCHEMBL1074507 | 0.82 | ACKR3 (0.77) | ACKR3CNR2TP53SMN1; SMN2POLB | |
| SCHEMBL1073605 | 0.80 | ACKR3 (0.80) | ACKR3CNR2THRBMAPTRXFP1 | |
| SCHEMBL3376866 | 0.77 | ACKR3 (0.84) | ACKR3CNR2MAPTTP53SMN1; SMN2 | |
| SCHEMBL1072793 | 0.77 | ACKR3 (0.78) | ACKR3MAPTGAATP53SMN1; SMN2 | |
| SCHEMBL1549473 | 0.77 | ACKR3 (0.78) | ACKR3CNR2MAPTTP53SMN1; SMN2 | |
| SCHEMBL1075524 | 0.77 | ACKR3 (0.78) | ACKR3CNR2MAPTTP53SMN1; SMN2 | |
| SCHEMBL1074655 | 0.76 | ACKR3 (0.51) | ACKR3CNR2THRBMAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954274-B8 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2011-01-12 | — | — | EP | disclosed |
| EP-1954274-A4 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX INC (US) | 2009-01-07 | — | — | EP | disclosed |
| EP-1954274-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | ChemoCentryx Inc (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007059108-A2 | SUBSTITUTED QUINOLONES AND METHODS OF USE | CHEMOCENTRYX, INC. (US) | 2007-05-24 | — | — | WO | disclosed |