Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.56 |
| ▸ | CA6 | P23280 | 5/20 | 0.56 |
| ▸ | CA7 | P43166 | 5/20 | 0.56 |
| ▸ | CA9 | Q16790 | 5/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.53 |
| ▸ | CA4 | P22748 | 4/20 | 0.53 |
| ▸ | CA5A | P35218 | 4/20 | 0.53 |
| ▸ | CA3 | P07451 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL6240702 | 1.00 | CA12 (0.56) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL27525013 | 0.97 | CA12 (0.59) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL9100273 | 0.97 | CA12 (0.59) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL9716193 | 0.97 | CA12 (0.59) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL3657736 | 0.97 | CA12 (0.59) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL1565417 | 0.97 | CA12 (0.59) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL863599 | 0.97 | CA12 (0.59) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL18288 | 0.97 | CA12 (0.59) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL19612785 | 0.94 | CA12 (0.56) | CA12CA6CA7CA9CA14 | |
| Acetic Acid SCHEMBL11072809 | 0.94 | CA12 (0.56) | CA12CA6CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10064818-B2 | Compositions and methods for the treatment of presbyopia | Presbyopia Therapies, LLC (US) | 2018-09-04 | — | — | US | claimed |
| EP-3310336-A1 | STORAGE STABLE COMPOSITIONS AND METHODS FOR THE TREATMENT OF REFRACTIVE ERRORS OF THE EYE | Presbyopia Therapies, LLC (US) | 2018-04-25 | — | — | EP | claimed |
| CN-107920984-A | Storage stable compositions and methods for treating refractive errors of the eye | 远视眼治疗有限责任公司 | 2018-04-17 | — | — | CN | claimed |
| CN-107847492-A | Composition for improving distance vision and treating ametropia of eyes | 远视眼治疗有限责任公司 | 2018-03-27 | — | — | CN | claimed |
| WO-2016205068-A1 | STORAGE STABLE COMPOSITIONS AND METHODS FOR THE TREATMENT OF REFRACTIVE ERRORS OF THE EYE | Presbyopia Therapies, LLC (US) | 2016-12-22 | — | — | WO | claimed |
| CN-105792815-A | Compositions and methods for the treatment of presbyopia | 远视眼治疗有限责任公司 | 2016-07-20 | — | — | CN | claimed |
| EP-3038610-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRESBYOPIA | Presbyopia Therapies, LLC (US) | 2016-07-06 | — | — | EP | claimed |
| US-9320709-B2 | Storage stable compositions and methods for the treatment of refractive errors of the eye | PRESBYOPIA THERAPIES LLC (US) | 2016-04-26 | — | — | US | claimed |
| US-9314427-B2 | Compositions and methods for the improvement of distance vision and the treatment of refractive errors of the eye | PRESBYOPIA THERAPIES LLC (US) | 2016-04-19 | — | — | US | claimed |
| US-20160008278-A1 | Compositions and Methods for the Treatment of Presbyopia | LENZ THERAPEUTICS OPERATIONS, INC. | 2016-01-14 | — | — | US | claimed |
| US-20150290126-A1 | Compositions and Methods for the Improvement of Distance Vision and the Treatment of Refractive Errors of the Eye | LENZ THERAPEUTICS OPERATIONS, INC. | 2015-10-15 | — | — | US | claimed |
| US-20150290125-A1 | Storage Stable Compositions and Methods for the Treatment of Refractive Errors of the Eye | LENZ THERAPEUTICS OPERATIONS, INC. | 2015-10-15 | — | — | US | claimed |
| WO-2015031186-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PRESBYOPIA | PRESBYOPIA THERAPLIES, LLC (US) | 2015-03-05 | — | — | WO | claimed |
| EP-4385521-A2 | STORAGE STABLE COMPOSITIONS AND METHODS FOR THE TREATMENT OF REFRACTIVE ERRORS OF THE EYE | Lenz Therapeutics, Inc. (US) | 2024-06-19 | — | — | EP | disclosed |
| US-20240091207-A1 | COMPOSITIONS AND METHODS FOR STORAGE STABLE OPHTHALMIC DRUGS | LENZ THERAPEUTICS OPERATIONS, INC. | 2024-03-21 | — | — | US | disclosed |
| WO-2023114347-A9 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF EYE CONDITIONS | LENZ THERAPEUTICS, INC. (US) | 2024-03-07 | — | — | WO | disclosed |
| WO-2009117057-A1 | OPHTHALMIC SOLUTIONS DISPLAYING IMPROVED EFFICACY | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| US-20090239775-A1 | OPHTHALMIC SOLUTIONS DISPLAYING IMPROVED EFFICACY | JOHNSON & JOHNSON VISION CARE, INC. | 2009-09-24 | — | — | US | disclosed |
| WO-2009005601-A1 | STABILIZED OPHTHALMIC SOLUTIONS | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2009-01-08 | — | — | WO | disclosed |
| US-20090004288-A1 | STABILIZED OPHTHALMIC SOLUTIONS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-01-01 | — | — | US | disclosed |