Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.65 |
| ▸ | RXRA | P19793 | 5/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.58 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.58 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.58 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.58 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.58 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.58 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.58 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10741388 | 0.87 | PPARG (0.86) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL10740005 | 0.87 | CA12 (0.66) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL7632658 | 0.86 | CYP1A2 (0.78) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL15109004 | 0.85 | PPARG (0.60) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL20016373 | 0.85 | PPARG (0.60) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL15108976 | 0.84 | PPARG (0.61) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL15108975 | 0.84 | PPARG (0.73) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL24062023 | 0.82 | PPARG (0.57) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL8155275 | 0.82 | PPARG (0.57) | PPARGRXRACYP1A2MAPTMAPK1 | |
| SCHEMBL15120735 | 0.82 | PPARG (0.56) | PPARGRXRACYP1A2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4656190-A | PLATELET ACTIVATING FACTOR | MERCK & CO., INC. (US) | 1987-04-07 | — | — | US | disclosed |
| EP-0142801-A2 | Indene derivatives useful as paf-antagonists | MERCK & CO. INC. (US) | 1985-05-29 | — | — | EP | disclosed |