Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.72 |
| ▸ | PPARD | Q03181 | 2/20 | 0.72 |
| ▸ | PPARA | Q07869 | 2/20 | 0.72 |
| ▸ | CYSLTR2 | Q9NS75 | 15/20 | 0.67 |
| ▸ | CYSLTR1 | Q9Y271 | 15/20 | 0.67 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10743714 | 0.99 | PPARG (0.71) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10743000 | 0.99 | PPARG (0.71) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10685300 | 0.99 | PPARG (0.71) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10687224 | 0.92 | CYSLTR2 (0.81) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10690160 | 0.90 | CYSLTR2 (0.82) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10690867 | 0.89 | CYSLTR2 (0.66) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10743286 | 0.88 | CYSLTR2 (0.67) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10739964 | 0.88 | CYSLTR2 (0.67) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL10690172 | 0.88 | CYSLTR2 (0.70) | PPARGPPARDPPARACYSLTR2CYSLTR1 | |
| SCHEMBL9301387 | 0.88 | CYSLTR2 (0.85) | PPARGPPARDPPARACYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672066-A | TREATMENT OF ALLERGIC CONDITIONS AND CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1987-06-09 | — | — | US | disclosed |
| US-4663332-A | ANTIALLERGIC AGENTS, CARDIOVASCULAR DISORDERS | HOFFMAN-LA ROCHE INC. (US) | 1987-05-05 | — | — | US | disclosed |
| US-4628115-A | LEUKOTRIENE ANTAGONISTS | HOFFMANN-LA ROCHE INC. (US) | 1986-12-09 | — | — | US | disclosed |