Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 11/20 | 0.46 |
| ▸ | JAK2 | O60674 | 6/20 | 0.33 |
| ▸ | JAK1 | P23458 | 6/20 | 0.33 |
| ▸ | JAK3 | P52333 | 6/20 | 0.33 |
| ▸ | TYK2 | P29597 | 5/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.33 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.33 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.33 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.33 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.33 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.33 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.33 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.33 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.33 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4357594 | 0.92 | ALK (0.49) | ALKJAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL1076455 | 0.89 | ALK (0.48) | ALKJAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL4353822 | 0.88 | ALK (0.52) | ALKJAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL4357237 | 0.88 | ALK (0.51) | ALKJAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL4357325 | 0.88 | ALK (0.47) | ALKJAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL4362007 | 0.88 | ALK (0.48) | ALKJAK2JAK1JAK3TYK2 | |
| SCHEMBL4360904 | 0.88 | ALK (0.54) | ALKJAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL4361071 | 0.87 | ALK (0.47) | ALKJAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL4359097 | 0.86 | ALK (0.51) | ALKJAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL4361257 | 0.86 | ALK (0.49) | ALKJAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |