Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.60 |
| ▸ | GUSB | P08236 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 4/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10740756 | 0.89 | PDE5A (0.62) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10734339 | 0.84 | PDE5A (0.70) | PDE5AKDM4EALDH1A1HPGDPDE10A | |
| SCHEMBL12088079 | 0.84 | PDE5A (0.68) | PDE5AGUSBPDE4APDE4BPDE4C | |
| SCHEMBL9635639 | 0.84 | PDE5A (0.62) | PDE5AGUSBPDE4APDE4BPDE4C | |
| SCHEMBL10736882 | 0.83 | MAOB (0.48) | PDE5AGUSBPDE4APDE4BPDE4C | |
| SCHEMBL10733689 | 0.83 | PDE5A (0.46) | PDE5AGUSBPDE4APDE4BPDE4C | |
| SCHEMBL10736109 | 0.83 | SMN1; SMN2 (0.48) | PDE5AGUSBKDM4EUSP2ALDH1A1 | |
| SCHEMBL10742508 | 0.83 | PDE5A (0.46) | PDE5AGUSBPDE4APDE4BPDE4C | |
| SCHEMBL10740066 | 0.81 | PDE2A (0.49) | PDE5AGUSBKDM4EUSP2ALDH1A1 | |
| SCHEMBL10740174 | 0.80 | PDE5A (0.39) | PDE5AGUSBKDM4EUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4654344-A | ALSO AFFECT BLOOD PRESSURE AND MYOCARDIAL CONTRACTIONS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1987-03-31 | — | — | US | disclosed |
| US-4575505-A | Pharmaceutical compositions containing 2-aryltetraazaindenes for treating ulcers or cardiac insufficiency or blood pressure abnormalities | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-03-11 | — | — | US | disclosed |
| US-4477454-A | INDOTROPIC AGENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-16 | — | — | US | disclosed |
| EP-0093951-A2 | 2-Aryl-tetraazaindenes | MERCK PATENT GmbH (DE) | 1983-11-16 | — | — | EP | disclosed |