Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.54 |
| ▸ | STK4 | Q13043 | 1/20 | 0.47 |
| ▸ | STK3 | Q13188 | 1/20 | 0.47 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.47 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 15/20 | 0.46 |
| ▸ | JAK1 | P23458 | 15/20 | 0.46 |
| ▸ | JAK3 | P52333 | 15/20 | 0.46 |
| ▸ | TYK2 | P29597 | 13/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359366 | 0.81 | ALK (0.71) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL1075441 | 0.81 | ALK (0.58) | ALKSTK4STK3STK26STK24 | |
| Trifluoroacetic Acid SCHEMBL1076356 | 0.81 | ALK (0.60) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL4368492 | 0.81 | ALK (0.55) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL13622764 | 0.80 | ALK (0.55) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL4356515 | 0.80 | ALK (0.61) | ALKSTK4STK3STK26STK24 | |
| Trifluoroacetic Acid SCHEMBL1073536 | 0.79 | ALK (0.53) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL4359278 | 0.78 | ALK (0.52) | ALKSTK4STK3STK26STK24 | |
| Trifluoroacetic Acid SCHEMBL1073296 | 0.78 | ALK (0.52) | ALKSTK4STK3STK26STK24 | |
| Trifluoroacetic Acid SCHEMBL1071772 | 0.78 | ALK (0.52) | ALKSTK4STK3STK26STK24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |