Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 13/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.54 |
| ▸ | PDE2A | O00408 | 3/20 | 0.52 |
| ▸ | PDE1A | P54750 | 2/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10739759 | 0.78 | PDE3B (0.67) | PDE3APDE3BPDE2APDE1APDE1B | |
| SCHEMBL10625021 | 0.77 | PDE3B (0.64) | PDE3APDE3BPDE2APDE1APDE1B | |
| SCHEMBL10741399 | 0.77 | PDE3B (0.63) | PDE3APDE3BPDE2APDE1APDE1B | |
| SCHEMBL10745218 | 0.74 | PDE3B (0.61) | PDE3APDE3BBRAFPDE4BHRH3 | |
| SCHEMBL10746007 | 0.73 | PDE3B (0.64) | PDE3APDE3BBRAFPDE4BHRH3 | |
| SCHEMBL10744031 | 0.71 | PDE3B (0.64) | PDE3APDE3BPDE2AHRH3 | |
| SCHEMBL11100082 | 0.70 | PDE3B (0.60) | PDE3APDE3BHRH3KCNH2GPR119 | |
| SCHEMBL10742719 | 0.70 | PDE3B (0.60) | PDE3APDE3BBRAFPDE4BHRH3 | |
| SCHEMBL11098748 | 0.70 | PDE3A (0.60) | PDE3APDE3BPDE2ABRAFPDE4B | |
| SCHEMBL10738989 | 0.70 | PDE3A (0.62) | PDE3APDE3BPDE2APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4602019-A | Indeno[1,2-c]pyridazin-3-one derivatives useful as cardiotonic and antihypertensive agents | WARNER-LAMBERT COMPANY (US) | 1986-07-22 | — | — | US | claimed |
| EP-0124314-A2 | Substituted-3H-indeno(1,2-c)pyridazin-3-ones | WARNER-LAMBERT COMPANY (US) | 1984-11-07 | — | — | EP | claimed |
| US-4701453-A | Substituted indeno-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1987-10-20 | — | — | US | disclosed |
| US-4602019-A | Indeno[1,2-c]pyridazin-3-one derivatives useful as cardiotonic and antihypertensive agents | WARNER-LAMBERT COMPANY (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0124314-A2 | Substituted-3H-indeno(1,2-c)pyridazin-3-ones | WARNER-LAMBERT COMPANY (US) | 1984-11-07 | — | — | EP | disclosed |