Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.78 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.78 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.78 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.78 |
| ▸ | HTT | P42858 | 2/20 | 0.78 |
| ▸ | MLNR | O43193 | 1/20 | 0.78 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.78 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.78 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.78 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10744188 | 1.00 | MEN1 (0.78) | MEN1KMT2AADORA3CACNA1CCACNA1B | |
| SCHEMBL10745195 | 0.95 | CACNA1C (0.75) | MEN1KMT2AADORA3CACNA1CCACNA1B | |
| SCHEMBL10745200 | 0.95 | CACNA1C (0.75) | MEN1KMT2AADORA3CACNA1CCACNA1B | |
| SCHEMBL9835079 | 0.95 | MEN1 (0.71) | MEN1KMT2AADORA3CACNA1CCACNA1B | |
| SCHEMBL9835087 | 0.95 | MEN1 (0.71) | MEN1KMT2AADORA3CACNA1CCACNA1B | |
| SCHEMBL9831212 | 0.94 | MEN1 (0.70) | MEN1KMT2AADORA3CACNA1CCACNA1B | |
| SCHEMBL9831217 | 0.94 | MEN1 (0.70) | MEN1KMT2AADORA3CACNA1CCACNA1B | |
| SCHEMBL9833239 | 0.94 | CACNA1B (0.83) | MEN1KMT2AADORA3CACNA1CCACNA1B | |
| SCHEMBL10744635 | 0.92 | MEN1 (0.68) | MEN1KMT2AADORA3CACNA1CCACNA1B | |
| SCHEMBL10744627 | 0.92 | MEN1 (0.68) | MEN1KMT2AADORA3CACNA1CCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672068-A | Antihypertensive 1,4-dihydropyridines having a conjugated ester | FUJIREBIO KABUSHIKI KAISHA (JP) | 1987-06-09 | — | — | US | disclosed |
| EP-0161877-A2 | 1,4-dihydropyridine derivatives, methods for their production and pharmaceutical compositions comprising the same | FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. (JP) | 1985-11-21 | — | — | EP | disclosed |