Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 6/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14017318 | 0.97 | MAPT (0.65) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL9828298 | 0.93 | GAA (0.69) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL10752984 | 0.82 | MAPT (0.74) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL10741943 | 0.81 | MAPT (0.71) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL14044219 | 0.79 | MAPT (0.69) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL10716480 | 0.78 | GAA (0.67) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL6218060 | 0.78 | SLC6A4 (0.49) | HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL7676694 | 0.77 | SLC6A4 (0.49) | HTR1ASLC6A4 | |
| SCHEMBL21225808 | 0.77 | MAPT (0.90) | MAPTMEN1KMT2ALMNATDP1 | |
| SCHEMBL27842093 | 0.77 | SLC6A4 (0.64) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4672067-A | 5-substituted 3-aminoalkyl indoles useful in treatment of migraine | GLAXO GROUP LIMITED (GB) | 1987-06-09 | — | — | US | disclosed |
| US-4252803-A | HYPOTENSIVE AGENTS, ANALGESICS | GLAXO GROUP LIMITED (GB) | 1981-02-24 | — | — | US | disclosed |