⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL27530614 | 0.95 | TSHR (0.43) | — | |
| Pyridazine SCHEMBL11423 | 0.89 | TSHR (0.42) | — | |
| Pyridazine SCHEMBL5104 | 0.89 | — | — | |
| Pyridazine SCHEMBL29471424 | 0.89 | — | — | |
| Pyridazine SCHEMBL27489974 | 0.86 | — | — | |
| Pyridazine SCHEMBL5361937 | 0.84 | — | — | |
| Pyridazine SCHEMBL21222853 | 0.84 | — | — | |
| Pyridazine SCHEMBL21405425 | 0.84 | — | — | |
| Pyridazine SCHEMBL21626119 | 0.84 | TSHR (0.39) | — | |
| Benzene SCHEMBL250829 | 0.84 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102627612-A | Two novel dihydralazine sulphate pharmaceutical co-crystals and preparation method thereof | JILIN SANSHANEN TECHNOLOGY DEV CO LTD | 2012-08-08 | — | — | CN | claimed |
| CN-102627612-B | Two novel dihydralazine sulphate pharmaceutical co-crystals and preparation method thereof | JILIN SANSHANEN TECHNOLOGY DEV CO LTD | 2014-04-16 | — | — | CN | disclosed |
| CN-102627612-A | Two novel dihydralazine sulphate pharmaceutical co-crystals and preparation method thereof | JILIN SANSHANEN TECHNOLOGY DEV CO LTD | 2012-08-08 | — | — | CN | disclosed |
| CN-101039701-A | Prodrugs and codrug comprising a biocleavable disulfide linker | NICHOLAS PIRAMAL INDIA LTD (IN) | 2007-09-19 | — | — | CN | disclosed |
| US-4670437-A | INFLUENZA | ELI LILLY AND COMPANY (US) | 1987-06-02 | — | — | US | disclosed |
| EP-0009655-B1 | 6-AMINO SUBSTITUTED N-PYRROLYL-3-PYRIDAZINE AMINES, THEIR PREPARATION, AND PHARMACEUTICALLY ANTIHYPERTENSIVE COMPOSITIONS CONTAINING THEM | GRUPPO LEPETIT S.P.A. (IT) | 1983-05-11 | — | — | EP | disclosed |