Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 19/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 19/20 | 0.51 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10755406 | 0.90 | PDE3B (0.51) | PDE3BPDE3AP2RY12PDE4APDE4B | |
| SCHEMBL10757307 | 0.88 | PDE3B (0.56) | PDE3BPDE3AP2RY12PDE4APDE4B | |
| SCHEMBL10754250 | 0.87 | PDE3B (0.58) | PDE3BPDE3AP2RY12PDE4APDE4B | |
| SCHEMBL10756379 | 0.85 | PDE3B (0.55) | PDE3BPDE3AP2RY12PDE4APDE4B | |
| SCHEMBL10753591 | 0.83 | PDE3B (0.49) | PDE3BPDE3AP2RY12 | |
| SCHEMBL10757558 | 0.81 | PDE3B (0.57) | PDE3BPDE3AP2RY12PDE4APDE4B | |
| SCHEMBL10754647 | 0.80 | PDE3B (0.67) | PDE3BPDE3AP2RY12PDE4APDE4B | |
| SCHEMBL10752625 | 0.78 | PDE3B (0.63) | PDE3BPDE3AP2RY12PDE4APDE4B | |
| SCHEMBL10755080 | 0.77 | PDE3B (0.64) | PDE3BPDE3AP2RY12 | |
| SCHEMBL10758038 | 0.76 | PDE3B (0.59) | PDE3BPDE3AP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4690925-A | ANTITHROMBOTIC ACTIVITY, CARDIOTONIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0153152-A2 | (2-Oxo-1,2,3,5-tetrahydroimidazo-/2,1-b/quinnazolinyl)-oxyalkylamides, their preparation, compositions containing them and their use in making medicaments | SYNTEX (U.S.A.) INC. (US) | 1985-08-28 | — | — | EP | disclosed |