Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.45 |
| ▸ | TYK2 | P29597 | 12/20 | 0.45 |
| ▸ | JAK1 | P23458 | 9/20 | 0.45 |
| ▸ | JAK3 | P52333 | 8/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.45 |
| ▸ | FLT3 | P36888 | 11/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.39 |
| ▸ | CDK2 | P24941 | 9/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.39 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1074237 | 0.86 | JAK2 (0.58) | JAK2TYK2JAK1JAK3ALK | |
| Trifluoroacetic Acid SCHEMBL4360464 | 0.80 | JAK2 (0.51) | JAK2TYK2JAK1JAK3ALK | |
| SCHEMBL1073858 | 0.79 | JAK2 (0.57) | JAK2TYK2JAK1JAK3ALK | |
| SCHEMBL1074333 | 0.76 | JAK2 (0.57) | JAK2TYK2JAK1JAK3ALK | |
| SCHEMBL4354829 | 0.75 | JAK2 (0.54) | JAK2TYK2JAK1JAK3ALK | |
| SCHEMBL1075636 | 0.75 | JAK2 (0.52) | JAK2TYK2JAK1JAK3ALK | |
| SCHEMBL1075459 | 0.75 | JAK2 (0.52) | JAK2TYK2JAK1JAK3ALK | |
| SCHEMBL13633073 | 0.75 | JAK2 (0.44) | JAK2TYK2JAK1JAK3ALK | |
| Trifluoroacetic Acid SCHEMBL1074371 | 0.74 | JAK2 (0.51) | JAK2TYK2JAK1JAK3ALK | |
| SCHEMBL13623168 | 0.72 | JAK2 (0.48) | JAK2TYK2JAK1JAK3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |