Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 11/20 | 0.50 |
| ▸ | STK4 | Q13043 | 1/20 | 0.40 |
| ▸ | STK3 | Q13188 | 1/20 | 0.40 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.40 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 12/20 | 0.40 |
| ▸ | JAK1 | P23458 | 12/20 | 0.40 |
| ▸ | JAK3 | P52333 | 12/20 | 0.40 |
| ▸ | TYK2 | P29597 | 11/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1076343 | 0.87 | ALK (0.54) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL1074508 | 0.86 | ALK (0.56) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL1073607 | 0.86 | ALK (0.55) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL13622883 | 0.86 | ALK (0.54) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL13622884 | 0.85 | ALK (0.54) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL4360155 | 0.85 | ALK (0.58) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL1074423 | 0.85 | ALK (0.55) | ALKSTK4STK3STK26STK24 | |
| SCHEMBL1075412 | 0.85 | ALK (0.52) | ALKSTK4STK3STK26STK24 | |
| Hydrochloric Acid SCHEMBL1074826 | 0.84 | ALK (0.53) | ALKSTK4STK3STK26STK24 | |
| Trifluoroacetic Acid SCHEMBL1075661 | 0.84 | ALK (0.51) | ALKSTK4STK3STK26STK24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |