Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1077041 | 0.82 | NTRK1 (0.56) | JAK2NTRK1SLC6A4HRH3KDM4E | |
| SCHEMBL4106380 | 0.79 | JAK2 (0.53) | JAK2NTRK1SLC6A4HRH3KDM4E | |
| SCHEMBL4293207 | 0.77 | JAK2 (0.53) | JAK2NTRK1SLC6A4HRH3KDM4E | |
| SCHEMBL4104900 | 0.76 | JAK2 (0.50) | JAK2NTRK1SLC6A4HRH3KDM4E | |
| SCHEMBL2694614 | 0.72 | NTRK1 (0.89) | JAK2NTRK1 | |
| SCHEMBL946646 | 0.72 | NTRK1 (0.89) | JAK2NTRK1 | |
| SCHEMBL19560119 | 0.72 | JAK2 (0.44) | JAK2NTRK1HRH3KDM4EALDH1A1 | |
| SCHEMBL2692019 | 0.71 | NTRK1 (1.00) | JAK2NTRK1 | |
| SCHEMBL2692021 | 0.71 | NTRK1 (1.00) | JAK2NTRK1 | |
| Hydrochloric Acid SCHEMBL944968 | 0.71 | NTRK1 (0.86) | JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |