Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PTGIR | P43119 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 2/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10758403 | 0.99 | HDAC2 (0.56) | HDAC2HDAC3PTK2HDAC1HDAC8 | |
| SCHEMBL10762838 | 0.99 | HDAC2 (0.56) | HDAC2HDAC3PTK2HDAC1HDAC8 | |
| SCHEMBL10758321 | 0.99 | HDAC2 (0.56) | HDAC2HDAC3PTK2HDAC1HDAC8 | |
| SCHEMBL10754699 | 0.99 | HDAC2 (0.56) | HDAC2HDAC3PTK2HDAC1HDAC8 | |
| SCHEMBL10764814 | 0.99 | HDAC2 (0.56) | HDAC2HDAC3PTK2HDAC1HDAC8 | |
| SCHEMBL10755254 | 0.99 | HDAC2 (0.56) | HDAC2HDAC3PTK2HDAC1HDAC8 | |
| SCHEMBL10754564 | 0.96 | MEN1 (0.55) | HDAC2HDAC3PTK2HDAC1HDAC8 | |
| SCHEMBL10758906 | 0.91 | MEN1 (0.64) | HDAC2HDAC3PTK2HDAC1HDAC8 | |
| SCHEMBL10755178 | 0.91 | HDAC2 (0.52) | HDAC2HDAC3PTK2HDAC1HDAC8 | |
| SCHEMBL10757716 | 0.91 | HDAC2 (0.52) | HDAC2HDAC3PTK2HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0130526-B1 | IMIDAZOL-2-YL MERCAPTO ALKANOIC ACIDS, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | A. Nattermann & Cie. GmbH (DE) | 1987-12-09 | — | — | EP | disclosed |
| US-4654358-A | 1,4,5-triphenylimidazol-2-yl mercapto alkanoic acids, useful against inflammation and diseases responding to lipid lowering | A. NATTERMANN & CIE GMBH (DE) | 1987-03-31 | — | — | US | disclosed |