Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.49 |
| ▸ | JAK2 | O60674 | 9/20 | 0.47 |
| ▸ | JAK1 | P23458 | 9/20 | 0.47 |
| ▸ | JAK3 | P52333 | 9/20 | 0.47 |
| ▸ | TYK2 | P29597 | 8/20 | 0.47 |
| ▸ | STK4 | Q13043 | 2/20 | 0.34 |
| ▸ | STK3 | Q13188 | 2/20 | 0.34 |
| ▸ | STK26 | Q9P289 | 2/20 | 0.34 |
| ▸ | STK24 | Q9Y6E0 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1075045 | 0.83 | ALK (0.61) | ALKJAK2JAK1JAK3TYK2 | |
| SCHEMBL4357882 | 0.82 | ALK (0.57) | ALKJAK2JAK1JAK3TYK2 | |
| SCHEMBL13623317 | 0.82 | ALK (0.53) | ALKJAK2JAK1JAK3TYK2 | |
| Hydrochloric Acid SCHEMBL4355865 | 0.81 | ALK (0.56) | ALKJAK2JAK1JAK3TYK2 | |
| SCHEMBL1075435 | 0.79 | JAK2 (0.45) | ALKJAK2JAK1JAK3TYK2 | |
| SCHEMBL1076209 | 0.78 | JAK2 (0.52) | ALKJAK2JAK1JAK3TYK2 | |
| SCHEMBL4360558 | 0.77 | ALK (0.52) | ALKJAK2JAK1JAK3TYK2 | |
| SCHEMBL4361234 | 0.77 | ALK (0.55) | ALKJAK2JAK1JAK3TYK2 | |
| SCHEMBL1075467 | 0.77 | JAK2 (0.53) | ALKJAK2JAK1JAK3TYK2 | |
| Trifluoroacetic Acid SCHEMBL1072466 | 0.76 | JAK2 (0.66) | ALKJAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274288-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | Incyte Corporation (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |