SCHEMBL1075911

SCHEMBL1075911

[SiH2]=CCC1([SiH3])CCCCO1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL171443 0.79
SCHEMBL28108721 0.79
SCHEMBL29182650 0.78
SCHEMBL20873772 0.78
SCHEMBL10771287 0.78
SCHEMBL1691828 0.76
SCHEMBL28858413 0.76
SCHEMBL8760701 0.75
SCHEMBL28141228 0.75
SCHEMBL28146912 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3494960-B1 STABILIZED COMPOSITIONS OF ALKYLATING AGENTS AND METHODS OF USING SAME HELSINN HEALTHCARE SA (CH) 2020-11-25 EP disclosed
EP-3377048-B1 ABUSE RESISTANT TRANSDERMAL DELIVERY DEVICES AND COMPOSITIONS COMPRISING AN OPIOID AGONIST AND A NON-TRANSDERMALLY DELIVERED N-OXIDE DERIVATIVE OF AN OPIOID ANTAGONIST FOR THE TREATMENT OF PAIN EURO CELTIQUE SA (LU) 2020-04-22 EP disclosed
EP-3494960-A1 STABILIZED COMPOSITIONS OF ALKYLATING AGENTS AND METHODS OF USING SAME Helsinn Healthcare SA (CH) 2019-06-12 EP disclosed
US-20180344726-A1 ABUSE RESISTANT TRANSDERMAL DELIVERY DEVICES AND COMPOSITIONS COMPRISING AN OPIOID AGONIST AND A NON-TRANSDERMALLY DELIVERED N-OXIDE DERIVATIVE OF AN OPIOID ANTAGONIST FOR THE TREATMENT OF PAIN EURO-CELTIQUE S.A. (LU) 2018-12-06 US disclosed
EP-3377048-A1 ABUSE RESISTANT TRANSDERMAL DELIVERY DEVICES AND COMPOSITIONS COMPRISING AN OPIOID AGONIST AND A NON-TRANSDERMALLY DELIVERED N-OXIDE DERIVATIVE OF AN OPIOID ANTAGONIST FOR THE TREATMENT OF PAIN Euro-Celtique S.A. (LU) 2018-09-26 EP disclosed
US-9382191-B2 Stabilized compositions of volatile alkylating agents and methods of using thereof ACTELION PHARMACEUTICALS, LTD. (CH) 2016-07-05 US disclosed
US-20140194526-A1 STABILIZED COMPOSITIONS OF VOLATILE ALKYLATING AGENTS AND METHODS OF USING THEREOF ACTELION PHARMACEUTICALS LTD. (CH) 2014-07-10 US disclosed
US-20140187810-A1 STABILIZED COMPOSITIONS OF ALKYLATING AGENTS AND METHODS OF USING SAME ACTELION PHARMACEUTICALS, LTD. (CH) 2014-07-03 US disclosed
US-20140155491-A1 Stabilized Compositions of Volatile Alkylating Agents and Methods of Using Thereof ACTELION PHARMACEUTICALS, LTD. (CH) 2014-06-05 US disclosed
US-20140142193-A1 Stabilized Compositions Of Alkylating Agents And Methods Of Using Same ACTELION PHARMACEUTICALS, LTD. (CH) 2014-05-22 US disclosed
WO-2004017941-A2 TRANSDERMAL DOSAGE FORM COMPRISING AN ACTIVE AGENT AND A SALT AND FREE-BASEFORM OF AN ANTAGONIST EURO-CELTIQUE, S.A. (LU) 2004-03-04 WO disclosed
US-20040033253-A1 Acyl opioid antagonists PURDUE PHARMA L.P. 2004-02-19 US disclosed
WO-2003070191-A2 TAMPER-RESISTANT TRANSDERMAL OPIOID DELIVERY DEVICES EURO-CELTIQUE, S.A. (LU) 2003-08-28 WO disclosed
US-20030125659-A1 Dosage of transdermal delivery systems EURO-CELTIQUE S.A. (LU) 2003-07-03 US disclosed
US-6569449-B1 For treatment of eating disorders, narcotic dependence and alcoholism. UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION 2003-05-27 US disclosed
US-5149538-A Misuse-resistive transdermal opioid dosage form WARNER-LAMBERT COMPANY (US) 1992-09-22 US disclosed
EP-0290482-A4 TRANSDERMAL ABSORPTION DOSAGE UNIT FOR NARCOTIC ANALGESICS AND ANTAGONISTS AND PROCESS FOR ADMINISTRATION 1990-11-28 EP disclosed
US-4806341-A BACKING LAYER, POLYMER MATRIX DISC WITH DRUG MICRODISPERSED THEREIN RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 1989-02-21 US disclosed
EP-0290482-A1 TRANSDERMAL ABSORPTION DOSAGE UNIT FOR NARCOTIC ANALGESICS AND ANTAGONISTS AND PROCESS FOR ADMINISTRATION. UNIV NEW JERSEY (US) 1988-11-17 EP disclosed
WO-1988001497-A1 TRANSDERMAL ABSORPTION DOSAGE UNIT FOR NARCOTIC ANALGESICS AND ANTAGONISTS AND PROCESS FOR ADMINISTRATION RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 1988-03-10 WO disclosed