Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.56 |
| ▸ | APP | P05067 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | STAT3 | P40763 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10762400 | 0.91 | PDE3B (0.56) | PDE3BPDE3AAPPALDH1A1ALOX5 | |
| SCHEMBL10766102 | 0.89 | PDE3B (0.58) | PDE3BPDE3AAPPALDH1A1TTR | |
| SCHEMBL10764462 | 0.85 | PDE3A (0.54) | PDE3BPDE3A | |
| SCHEMBL10762914 | 0.84 | PDE3A (0.51) | PDE3BPDE3AMAPTCYP1A2 | |
| SCHEMBL10767135 | 0.84 | PDE3A (0.53) | PDE3BPDE3AALDH1A1 | |
| SCHEMBL10766381 | 0.83 | PDE3A (0.50) | PDE3BPDE3AAPPMAPT | |
| SCHEMBL10764747 | 0.83 | PDE3A (0.50) | PDE3BPDE3AAPPMAPT | |
| SCHEMBL10763264 | 0.83 | PDE3B (0.51) | PDE3BPDE3AALDH1A1MAPTCYP1A2 | |
| SCHEMBL10760628 | 0.82 | PDE3A (0.51) | PDE3BPDE3AMAPT | |
| SCHEMBL10764318 | 0.81 | PDE3B (0.57) | PDE3BPDE3APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |