Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ceforanide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 10/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.57 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.57 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 9/20 | 0.57 |
| ▸ | MAPT | P10636 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ceforanide SCHEMBL14303761 | 1.00 | TDP1 (1.00) | TDP1HSD17B10LMNAKDM4EMEN1 | |
| Ceforanide SCHEMBL10760121 | 1.00 | TDP1 (1.00) | TDP1HSD17B10LMNAKDM4EMEN1 | |
| Ceforanide SCHEMBL122072 | 1.00 | TDP1 (1.00) | TDP1HSD17B10LMNAKDM4EMEN1 | |
| Ceforanide SCHEMBL27820426 | 0.99 | TDP1 (0.98) | TDP1HSD17B10LMNAKDM4EMEN1 | |
| Ceforanide SCHEMBL28528800 | 0.99 | TDP1 (0.98) | TDP1HSD17B10LMNAKDM4EMEN1 | |
| Ceforanide SCHEMBL9390322 | 0.94 | TDP1 (0.88) | TDP1HSD17B10LMNAKDM4EMEN1 | |
| SCHEMBL11395464 | 0.93 | TDP1 (0.88) | TDP1HSD17B10LMNAKDM4EMEN1 | |
| Ceforanide SCHEMBL11668090 | 0.93 | TDP1 (0.88) | TDP1HSD17B10LMNAKDM4EMEN1 | |
| Ceforanide SCHEMBL9390332 | 0.93 | TDP1 (0.87) | TDP1HSD17B10LMNAKDM4EMEN1 | |
| Ceforanide SCHEMBL10764451 | 0.93 | TDP1 (0.87) | TDP1HSD17B10LMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0106369-B1 | PURIFICATION OF CEFORANIDE | Bristol-Myers Company (US) | 1987-08-12 | — | — | EP | claimed |
| EP-0106369-A2 | Purification of ceforanide | Bristol-Myers Company (US) | 1984-04-25 | — | — | EP | claimed |
| EP-0106369-B1 | PURIFICATION OF CEFORANIDE | Bristol-Myers Company (US) | 1987-08-12 | — | — | EP | disclosed |
| US-4448958-A | SALT FORMATION WITH BENZYLDIMETHYLAMINE, DISSOLVING AND ADJUSTMENT OF PH TO CRYSTALLIZE | BRISTOL-MYERS COMPANY (US) | 1984-05-15 | — | — | US | disclosed |
| US-4448958-A | SALT FORMATION WITH BENZYLDIMETHYLAMINE, DISSOLVING AND ADJUSTMENT OF PH TO CRYSTALLIZE | BRISTOL-MYERS COMPANY (US) | 1984-05-15 | — | — | US | disclosed |