Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.51 |
| ▸ | BRAF | P15056 | 11/20 | 0.51 |
| ▸ | KDR | P35968 | 4/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.47 |
| ▸ | TEK | Q02763 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1078714 | 0.87 | LCK (0.63) | RAF1BRAFKDRMAPK14LCK | |
| SCHEMBL1149390 | 0.87 | LCK (0.47) | KDRMAPK14LCKJAK3TEK | |
| SCHEMBL1078661 | 0.84 | LCK (0.47) | BRAFKDRMAPK14LCKJAK3 | |
| SCHEMBL1149056 | 0.78 | LCK (0.42) | RAF1BRAFKDRMAPK14LCK | |
| SCHEMBL1149359 | 0.78 | ABL1 (0.53) | RAF1BRAFKDRMAPK14MAPK11 | |
| SCHEMBL1078560 | 0.78 | LCK (0.61) | RAF1BRAFKDRMAPK14LCK | |
| SCHEMBL1149695 | 0.77 | LCK (0.46) | RAF1BRAFKDRMAPK14LCK | |
| SCHEMBL1076598 | 0.77 | LCK (0.60) | RAF1BRAFKDRMAPK14LCK | |
| SCHEMBL1149752 | 0.77 | LCK (0.64) | RAF1BRAFKDRMAPK14LCK | |
| SCHEMBL1149100 | 0.76 | LCK (0.63) | RAF1BRAFKDRMAPK14LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
| EP-2269993-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | H1-2, H1-3, H1-0 | RAF1 781/4885BRAF 2498/4885KDR 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.