Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 17/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 17/20 | 0.59 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10652569 | 0.90 | KDM4E (0.66) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10764400 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10764489 | 0.87 | KDM4E (0.63) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| Siguazodan SCHEMBL5170622 | 0.86 | KDM4E (0.70) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| Siguazodan SCHEMBL6558367 | 0.86 | KDM4E (0.70) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10652516 | 0.86 | KDM4E (0.62) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10760066 | 0.85 | KDM4E (0.61) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10762827 | 0.85 | KDM4E (0.61) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10765293 | 0.85 | KDM4E (0.61) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10763778 | 0.85 | KDM4E (0.60) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208518-A2 | 6-Phenyl-pyridazinyl compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-01-14 | — | — | EP | claimed |
| EP-0208518-A2 | 6-Phenyl-pyridazinyl compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-01-14 | — | — | EP | disclosed |