Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10761515 | 0.88 | PDE3B (0.38) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10764873 | 0.85 | PDE3B (0.37) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10765095 | 0.85 | PDE3B (0.33) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10764583 | 0.83 | PDE3A (0.41) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10767519 | 0.81 | PDE3A (0.39) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10763903 | 0.81 | PDE3B (0.47) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10767406 | 0.80 | NPC1 (0.39) | PDE3BPDE3AALDH1A1 | |
| SCHEMBL10764068 | 0.80 | PDE3B (0.33) | PDE3BPDE3APBRM1BRD4CREBBP | |
| SCHEMBL10763886 | 0.79 | PDE3B (0.33) | PDE3BPDE3APBRM1BRD4CREBBP | |
| SCHEMBL10763597 | 0.79 | PDE3B (0.33) | PDE3BPDE3APBRM1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |