Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFB | P00751 | 8/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019300 | 0.82 | PKN1 (0.48) | CFB | |
| SCHEMBL11233387 | 0.82 | PDE2A (0.48) | PDE2APDE5AKDM4EPDE3BPDE3A | |
| SCHEMBL10760601 | 0.80 | MAPK10 (0.42) | CFBPDE2APDE5APDE3BPDE3A | |
| SCHEMBL11774181 | 0.78 | PDE2A (0.72) | PDE2APDE5AKDM4EPDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL11768135 | 0.77 | PDE2A (0.70) | PDE2APDE5AKDM4EPDE3BPDE3A | |
| SCHEMBL10691379 | 0.77 | PDE2A (0.46) | PDE2APDE5AKDM4EPDE3BPDE3A | |
| SCHEMBL10745392 | 0.76 | PDE2A (0.47) | CFBPDE2APDE5AKDM4EPDE3B | |
| SCHEMBL10762663 | 0.76 | PDE2A (0.45) | PDE2APDE5AKDM4EPDE3BPDE3A | |
| SCHEMBL10678386 | 0.73 | PDE5A (0.49) | PDE2APDE5AKDM4EPDE3BPDE3A | |
| SCHEMBL10673882 | 0.73 | PDE2A (0.48) | PDE2APDE5AKDM4EPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209707-A2 | 2-Aryl imidazoles, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-01-28 | — | — | EP | claimed |
| EP-0209707-A2 | 2-Aryl imidazoles, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-01-28 | — | — | EP | disclosed |