SCHEMBL1076901

SCHEMBL1076901

CCOc1cc(Oc2ccc(S(C)(=O)=O)nc2)cc2cc(C3=NCC(OC(C)=O)S3)[nH]c12

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 14/20 0.36
GPR119 Q8TDV5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4444174 0.88 GCK (0.34) GCK
SCHEMBL12806809 0.86 GCK (0.36) GCK
SCHEMBL1076899 0.86 GCK (0.38) GCK
SCHEMBL1677317 0.85 GCK (0.35) GCK
SCHEMBL12734466 0.85 GCK (0.35) GCK
SCHEMBL1678058 0.85 GCK (0.34) GCK
SCHEMBL12806953 0.84 GCK (0.35) GCK
SCHEMBL1677392 0.84 GCK (0.36) GCKGPR119
SCHEMBL1077510 0.84 GCK (0.34) GCK
SCHEMBL13665699 0.81 GCK (0.34) GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2276760-A1 FUSED RING COMPOUNDS AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2011-01-26 EP disclosed
WO-2009125873-A1 FUSED RING COMPOUNDS AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-10-15 WO disclosed