Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 7/20 | 0.52 |
| ▸ | BRD4 | O60885 | 5/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | JAK3 | P52333 | 4/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 7/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 4/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | YES1 | P07947 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1045772 | 0.86 | ZAP70 (0.67) | ZAP70BRD4JAK2JAK3BRDT | |
| SCHEMBL1049894 | 0.77 | ZAP70 (0.82) | ZAP70TYK2 | |
| SCHEMBL1044243 | 0.75 | ZAP70 (0.55) | ZAP70JAK2JAK3JAK1TYK2 | |
| SCHEMBL1046183 | 0.75 | AXL (0.51) | ZAP70BRD4JAK2JAK3BRDT | |
| SCHEMBL1048606 | 0.74 | ZAP70 (0.50) | ZAP70JAK2SYK | |
| SCHEMBL1046940 | 0.74 | ZAP70 (0.56) | ZAP70JAK2SYK | |
| SCHEMBL1045805 | 0.74 | ZAP70 (0.58) | ZAP70JAK2TYK2FLT3SYK | |
| SCHEMBL1049893 | 0.72 | ZAP70 (0.80) | ZAP70TYK2SYK | |
| SCHEMBL1045382 | 0.72 | ZAP70 (0.58) | ZAP70JAK2JAK3SRCSYK | |
| SCHEMBL1049221 | 0.71 | ZAP70 (0.61) | ZAP70BRD4JAK2FLT3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546370-B2 | Compounds and compositions as kinase inhibitors | IRM LLC (BM) | 2013-10-01 | — | — | US | disclosed |
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2011-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003798-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | FYN, SYK, RET | ZAP70 4/4885BRD4 2595/4885JAK2 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.