Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.53 |
| ▸ | KDR | P35968 | 7/20 | 0.53 |
| ▸ | JAK3 | P52333 | 5/20 | 0.53 |
| ▸ | TEK | Q02763 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | BTK | Q06187 | 2/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1078797 | 0.95 | BRAF (0.50) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1149064 | 0.91 | LCK (0.65) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1149045 | 0.90 | KDR (0.56) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1076762 | 0.89 | LCK (0.54) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1077383 | 0.89 | KDR (0.54) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1076887 | 0.89 | BRAF (0.51) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1078899 | 0.87 | LCK (0.64) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1079615 | 0.87 | LCK (0.49) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1082637 | 0.86 | ABL1 (0.55) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1078338 | 0.84 | DDR2 (0.54) | LCKMAPK14KDRJAK3TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |
| EP-2269993-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-01-05 | — | — | EP | disclosed |