Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 19/20 | 0.78 |
| ▸ | ACE2 | Q9BYF1 | 10/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10779298 | 1.00 | ACE (0.78) | ACEACE2 | |
| SCHEMBL10779271 | 0.87 | ACE (1.00) | ACEACE2 | |
| SCHEMBL10779265 | 0.87 | ACE (1.00) | ACEACE2 | |
| SCHEMBL10781977 | 0.87 | ACE (0.78) | ACEACE2 | |
| SCHEMBL10781971 | 0.87 | ACE (0.78) | ACEACE2 | |
| SCHEMBL11197216 | 0.86 | ACE (0.98) | ACEACE2 | |
| SCHEMBL10779490 | 0.86 | ACE (1.00) | ACEACE2 | |
| Lithium Ion SCHEMBL11197212 | 0.79 | ACE (0.84) | ACEACE2 | |
| SCHEMBL10779274 | 0.79 | ACE (0.63) | ACEACE2 | |
| SCHEMBL11295983 | 0.78 | ACE (0.66) | ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4716155-A | INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1987-12-29 | — | — | US | disclosed |
| EP-0083172-B1 | PHOSPHORUS CONTAINING COMPOUNDS | E.R. Squibb & Sons, Inc. (US) | 1987-09-16 | — | — | EP | disclosed |
| US-4555506-A | Phosphorus containing compounds and use as hypotensives | E. R. SQUIBB & SONS, INC. (US) | 1985-11-26 | — | — | US | disclosed |
| EP-0083172-A2 | Phosphorus containing compounds | E.R. Squibb & Sons, Inc. (US) | 1983-07-06 | — | — | EP | disclosed |