Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10934842 | 0.88 | MME (0.58) | MMEACEBRD4L3MBTL1KDM4E | |
| SCHEMBL10778809 | 0.83 | BRD4 (0.50) | BRD4L3MBTL1KDM4EALDH1A1KMT2A | |
| SCHEMBL10781404 | 0.81 | MME (0.52) | MMEACEL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL10778648 | 0.76 | MME (0.49) | MMEACEL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL13818079 | 0.74 | BRD4 (0.66) | BRD4L3MBTL1KDM4EALDH1A1KMT2A | |
| SCHEMBL10778631 | 0.74 | MME (0.49) | MMEACEL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL28751799 | 0.73 | BRD4 (0.56) | BRD4L3MBTL1KDM4EALDH1A1KMT2A | |
| SCHEMBL11113408 | 0.73 | MME (0.58) | MMEACEL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL10781458 | 0.72 | MME (0.56) | MMEACEL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL10783947 | 0.72 | MME (0.53) | MMEACEL3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0110484-B1 | DERIVATIVES OF AMINOPYRIDINECARBOXYLIC ACIDS, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Simes S.p.A. (IT) | 1987-09-02 | — | — | EP | disclosed |
| US-4528296-A | Derivatives of aminopyridinecarboxylic acids and pharmaceutical compositions containing them | SIMES, SOCIETA ITALIANA MEDICINALLE SINTETICI (IT) | 1985-07-09 | — | — | US | disclosed |
| EP-0110484-A1 | Derivatives of aminopyridinecarboxylic acids, methods for their preparation and pharmaceutical compositions containing them | Simes S.p.A. (IT) | 1984-06-13 | — | — | EP | disclosed |