Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.52 |
| ▸ | BRAF | P15056 | 6/20 | 0.51 |
| ▸ | KDR | P35968 | 6/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.51 |
| ▸ | LCK | P06239 | 6/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.51 |
| ▸ | TEK | Q02763 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 4/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.48 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1082637 | 0.92 | ABL1 (0.55) | ABL1BRAFKDRMAPK14LCK | |
| SCHEMBL1083477 | 0.92 | KDR (0.55) | ABL1BRAFKDRMAPK14LCK | |
| SCHEMBL1149222 | 0.91 | KDR (0.62) | ABL1BRAFKDRMAPK14LCK | |
| SCHEMBL1077442 | 0.90 | KDR (0.52) | ABL1BRAFKDRMAPK14LCK | |
| SCHEMBL1149236 | 0.88 | DDR2 (0.57) | ABL1BRAFKDRMAPK14LCK | |
| SCHEMBL1077229 | 0.88 | ABL1 (0.53) | ABL1BRAFKDRMAPK14LCK | |
| SCHEMBL1079625 | 0.84 | ABL1 (0.46) | ABL1BRAF | |
| SCHEMBL1079204 | 0.84 | KDR (0.56) | ABL1BRAFKDRMAPK14LCK | |
| SCHEMBL1077835 | 0.83 | ABL1 (0.47) | ABL1BRAFKDRMAPK14LCK | |
| SCHEMBL1078689 | 0.82 | LCK (0.61) | ABL1BRAFKDRMAPK14LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |
| EP-2269993-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-01-05 | — | — | EP | disclosed |