Acrylamide

Acrylamide

SCHEMBL1078602

C=C(C)C(=O)OCCC[N+](C)(C)C.C=CC(N)=O.[Br-]

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Acrylamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM5 known ✓ P08912 4/20 0.42
CHRM1 known ✓ P11229 4/20 0.42
CHRM3 known ✓ P20309 4/20 0.42
CHRM2 known ✓ P08172 3/20 0.42
CHRM4 known ✓ P08173 3/20 0.42
ACHE known ✓ P22303 1/20 0.34
TSHR P16473 7/20 0.46
THRB P10828 1/20 0.40
HTR1A P08908 2/20 0.40
CHRNB2 P17787 2/20 0.40
CHRNA7 P36544 2/20 0.40
CHRNA4 P43681 2/20 0.40
LMNA P02545 2/20 0.40
GALR3 O60755 2/20 0.40
CYP2C19 P33261 1/20 0.40
GAA P10253 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.37
PGR P06401 1/20 0.37
TBXA2R P21731 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acrylamide SCHEMBL2829270 0.91 CHRM1 (0.53) TSHRCHRM5CHRM1CHRM3CHRM2
Acrylamide SCHEMBL4918502 0.89 CHRM5 (0.55) TSHRCHRM5CHRM1CHRM3CHRM2
Acrylamide SCHEMBL199513 0.89 CHRM5 (0.55) TSHRCHRM5CHRM1CHRM3CHRM2
Bromide SCHEMBL1255402 0.89 TSHR (0.56) TSHRCHRM5CHRM1CHRM3CHRM2
Acrylamide SCHEMBL29142389 0.88 TSHR (0.63) TSHRTHRBACHEHPGD
SCHEMBL202124 0.87 TSHR (0.58) TSHRCHRM5CHRM1CHRM3CHRM2
Hydrochloric Acid SCHEMBL352728 0.87 TSHR (0.58) TSHRCHRM5CHRM1CHRM3CHRM2
Hydrochloric Acid SCHEMBL15703998 0.86 TSHR (0.50) TSHRCHRM5CHRM1CHRM3CHRM2
Iodide SCHEMBL1254986 0.85 TSHR (0.56) TSHRCHRM5CHRM1CHRM3CHRM2
SCHEMBL28077637 0.85 TSHR (0.56) TSHRCHRM5CHRM1CHRM3CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3370064-A1 REAGENT AND METHOD FOR MEASURING THROMBIN-ANTITHROMBIN COMPLEX LSI Medience Corporation (JP) 2018-09-05 EP claimed
US-20180238871-A1 REAGENT AND METHOD FOR MEASURING THROMBIN-ANTITHROMBIN COMPLEX PHC CORPORATION (JP) 2018-08-23 US claimed
CN-117990906-A Thrombin-antithrombin complex assay reagent and assay method 普和希株式会社 2024-05-07 CN disclosed
US-11378577-B2 Reagent and method for measuring thrombin-antithrombin complex LSI MEDIENCE CORPORATION (JP) 2022-07-05 US disclosed
US-11378577-B2 Reagent and method for measuring thrombin-antithrombin complex LSI MEDIENCE CORPORATION (JP) 2022-07-05 US disclosed
US-20190016909-A1 TEMPLATE SYNTHESIS OF POLYMERIC NANOMATERIALS BY INK-JET PRINTING UNIVERSITY OF NOTRE DAME DU LAC (US) 2019-01-17 US disclosed
EP-3370064-A1 REAGENT AND METHOD FOR MEASURING THROMBIN-ANTITHROMBIN COMPLEX LSI Medience Corporation (JP) 2018-09-05 EP disclosed
US-20180238871-A1 REAGENT AND METHOD FOR MEASURING THROMBIN-ANTITHROMBIN COMPLEX PHC CORPORATION (JP) 2018-08-23 US disclosed
US-20180238871-A1 REAGENT AND METHOD FOR MEASURING THROMBIN-ANTITHROMBIN COMPLEX PHC CORPORATION (JP) 2018-08-23 US disclosed
WO-2017123660-A1 TEMPLATE SYNTHESIS OF POLYMERIC MATERIALS BY INKJET PRINTING UNIVERSITY OF NOTRE DAME DU LAC (US) 2017-07-20 WO disclosed
US-8021716-B2 Polyelectrolyte-encapsulated pigments CLARIANT FINANCE (BVI) LIMITED (VG) 2011-09-20 US disclosed
US-7867592-B2 Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces EKSIGENT TECHNOLOGIES, INC. (US) 2011-01-11 US disclosed
EP-2131952-A1 METHODS, COMPOSITIONS AND DEVICES, INCLUDING ELECTROOSMOTIC PUMPS, COMPRISING COATED POROUS SURFACES Eksigent Technologies, LLC (US) 2009-12-16 EP disclosed
WO-2008094999-A1 METHODS, COMPOSITIONS AND DEVICES, INCLUDING ELECTROOSMOTIC PUMPS, COMPRISING COATED POROUS SURFACES EKSIGENT TECHNOLOGIES LLC (US) 2008-08-07 WO disclosed
US-20080179188-A1 METHODS, COMPOSITIONS AND DEVICES, INCLUDING ELECTROOSMOTIC PUMPS, COMPRISING COATED POROUS SURFACES EKSIGENT TECHNOLOGIES, INC. (US) 2008-07-31 US disclosed
US-20070224345-A1 Polyelectrolyte-encapsulated pigments CLARIANT INTERNATIONAL LTD 2007-09-27 US disclosed
US-7056554-B2 Production of polyelectrolyte capsules by surface precipitation MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) 2006-06-06 US disclosed
US-20040013738-A1 Encapsulation of liquid template particles MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFREN E.V. (DE) 2004-01-22 US disclosed
US-20030175517-A1 Production of polyelectrolyte capsules by surface precipitation MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) 2003-09-18 US disclosed