Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CES1 | P23141 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10789565 | 0.91 | TSHR (0.59) | TSHRGSK3BLMNAGAACES1 | |
| SCHEMBL240086 | 0.91 | GSK3B (0.71) | TSHRGSK3BLMNAGAACES1 | |
| SCHEMBL10789142 | 0.84 | GSK3B (0.62) | TSHRGSK3BLMNAGAACES1 | |
| SCHEMBL6650467 | 0.84 | GSK3B (0.62) | TSHRGSK3BLMNAGAACES1 | |
| SCHEMBL6756989 | 0.84 | TSHR (0.63) | TSHRGSK3BLMNAGAACES1 | |
| SCHEMBL4477185 | 0.84 | CES1 (0.70) | GSK3BCES1CA1CA2TDP1 | |
| SCHEMBL9734470 | 0.83 | GSK3B (0.67) | TSHRGSK3BLMNAGAACES1 | |
| SCHEMBL1982760 | 0.82 | GSK3B (0.66) | TSHRGSK3BCES1CA1CA2 | |
| SCHEMBL11705103 | 0.81 | GSK3B (0.65) | TSHRGSK3BGAACES1CA1 | |
| SCHEMBL10788268 | 0.81 | GSK3B (0.59) | TSHRGSK3BLMNAGAACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4683330-A | ANTICOAGULANTS, ANTIULCER AGENTS | THE UPJOHN COMPANY (US) | 1987-07-28 | — | — | US | disclosed |
| US-4668814-A | ANTIULCER AGENTS, ANTIASHMATICS, ANTICOAGULANTS | THE UPJOHN COMPANY (US) | 1987-05-26 | — | — | US | disclosed |
| US-4628110-A | Novel 9-substituted carbacyclin analogs | THE UPJOHN COMPANY (US) | 1986-12-09 | — | — | US | disclosed |
| US-4621100-A | Treatment of osteoporosis with prostaglandins | THE UPJOHN COMPANY (US) | 1986-11-04 | — | — | US | disclosed |
| EP-0089769-B1 | 9-SUBSTITUTED CARBACYCLIN ANALOGUES | THE UPJOHN COMPANY (US) | 1986-10-01 | — | — | EP | disclosed |
| EP-0092352-B1 | 9-SUBSTITUTED CARBACYCLINS | THE UPJOHN COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |
| EP-0086611-B1 | 9-SUBSTITUTED CARBACYCLIN ANALOGUES | THE UPJOHN COMPANY (US) | 1986-05-21 | — | — | EP | disclosed |
| US-4590297-A | Novel 9-substituted carbacyclin analogs | THE UPJOHN COMPANY (US) | 1986-05-20 | — | — | US | disclosed |
| EP-0087237-B1 | CARBACYCLIN ANALOGUES | THE UPJOHN COMPANY (US) | 1986-05-14 | — | — | EP | disclosed |
| US-4588823-A | 9-substituted carbacyclin analogs | THE UPJOHN COMPANY (US) | 1986-05-13 | — | — | US | disclosed |
| US-4160095-A | PROSTAGLANDINS; ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1979-07-03 | — | — | US | disclosed |
| US-4157441-A | PROSTAGLANDINS, ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1979-06-05 | — | — | US | disclosed |
| US-4151351-A | PROSTAGLANDINS, ANTIINFLAMMATORY | THE UPJOHN COMPANY (US) | 1979-04-24 | — | — | US | disclosed |
| US-4131738-A | 6-Hydroxy-PGE1 compounds | THE UPJOHN COMPANY (US) | 1978-12-26 | — | — | US | disclosed |
| US-4128713-A | 6,7-Didehydro-PGI1 compounds | THE UPJOHN COMPANY (US) | 1978-12-05 | — | — | US | disclosed |
| US-4126744-A | PROSTACYCLIN, MUSCLE STIMULANTS, PLATELET AGGREGATION INHIBITORS | THE UPJOHN COMPANY (US) | 1978-11-21 | — | — | US | disclosed |
| US-4112224-A | PROSTAGLANDIN | THE UPJOHN COMPANY (US) | 1978-09-05 | — | — | US | disclosed |
| US-4109082-A | PROSTACYCLIN ANALOGS; SMOOTH MUSCLE STIMULATORS | THE UPJOHN COMPANY (US) | 1978-08-22 | — | — | US | disclosed |
| US-4100192-A | Inter-phenylene-PG amides | THE UPJOHN COMPANY (US) | 1978-07-11 | — | — | US | disclosed |
| US-4097489-A | PROSTAGLANDINS | THE UPJOHN COMPANY (US) | 1978-06-27 | — | — | US | disclosed |