Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | TEK | Q02763 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 12/20 | 0.41 |
| ▸ | BRAF | P15056 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1082754 | 0.92 | LCK (0.44) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL1076926 | 0.89 | LCK (0.48) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL1083158 | 0.88 | LCK (0.50) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL1079336 | 0.88 | LCK (0.49) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL1077552 | 0.88 | LCK (0.49) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL1149288 | 0.87 | LCK (0.48) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL1080143 | 0.87 | LCK (0.50) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL1148921 | 0.86 | LCK (0.48) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL1078407 | 0.86 | LCK (0.48) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL1078927 | 0.86 | LCK (0.48) | LCKKDRJAK3MAPK14TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |
| EP-2269993-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-01-05 | — | — | EP | disclosed |