Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 6/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1047544 | 0.91 | JAK2 (0.57) | JAK3JAK2JAK1LCK | |
| SCHEMBL1050679 | 0.88 | JAK3 (0.60) | JAK3JAK2LCK | |
| SCHEMBL322904 | 0.80 | JAK2 (0.58) | JAK3JAK2JAK1LCK | |
| SCHEMBL1048617 | 0.79 | JAK3 (0.57) | JAK3LCK | |
| SCHEMBL1079222 | 0.78 | JAK3 (0.49) | JAK3JAK2LCK | |
| SCHEMBL1046539 | 0.77 | JAK3 (0.61) | JAK3JAK2LCK | |
| SCHEMBL1046674 | 0.77 | JAK3 (0.57) | JAK3JAK1LCK | |
| SCHEMBL1049395 | 0.77 | JAK3 (0.54) | JAK3LCK | |
| SCHEMBL1048571 | 0.77 | JAK3 (0.51) | JAK3JAK2LCK | |
| SCHEMBL322764 | 0.76 | JAK3 (0.57) | JAK3JAK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011003418-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-01-13 | — | — | WO | disclosed |