Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.61 |
| ▸ | LCK | P06239 | 11/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.61 |
| ▸ | TEK | Q02763 | 5/20 | 0.61 |
| ▸ | JAK3 | P52333 | 4/20 | 0.61 |
| ▸ | KIT | P10721 | 6/20 | 0.56 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.49 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1083293 | 0.91 | KDR (0.59) | KDRLCKMAPK14TEKJAK3 | |
| SCHEMBL1078899 | 0.91 | LCK (0.64) | KDRLCKMAPK14TEKJAK3 | |
| SCHEMBL1076917 | 0.90 | LCK (0.63) | KDRLCKMAPK14TEKJAK3 | |
| SCHEMBL1149446 | 0.90 | LCK (0.67) | KDRLCKMAPK14TEKJAK3 | |
| SCHEMBL1148998 | 0.90 | LCK (0.67) | KDRLCKMAPK14TEKJAK3 | |
| SCHEMBL1077306 | 0.89 | LCK (0.62) | KDRLCKMAPK14TEKJAK3 | |
| SCHEMBL1149349 | 0.89 | LCK (0.66) | KDRLCKMAPK14TEKJAK3 | |
| SCHEMBL1149176 | 0.88 | LCK (0.63) | KDRLCKMAPK14TEKJAK3 | |
| SCHEMBL1149181 | 0.88 | LCK (0.65) | KDRLCKMAPK14TEKJAK3 | |
| SCHEMBL1077026 | 0.88 | LCK (0.61) | KDRLCKMAPK14TEKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |
| EP-2269993-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-01-05 | — | — | EP | disclosed |