Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.57 |
| ▸ | RAF1 | P04049 | 13/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.52 |
| ▸ | TEK | Q02763 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1078749 | 0.92 | KDR (0.55) | BRAFRAF1KDRLCKJAK3 | |
| SCHEMBL1079833 | 0.86 | LCK (0.58) | BRAFRAF1KDRLCKJAK3 | |
| SCHEMBL1078814 | 0.86 | KDR (0.61) | BRAFRAF1KDRLCKJAK3 | |
| SCHEMBL1082634 | 0.86 | RAF1 (0.61) | BRAFRAF1KDRLCKJAK3 | |
| SCHEMBL1080552 | 0.85 | LCK (0.64) | BRAFRAF1KDRLCKJAK3 | |
| SCHEMBL1078032 | 0.85 | KDR (0.56) | BRAFRAF1KDRLCKJAK3 | |
| SCHEMBL1078464 | 0.84 | RAF1 (0.61) | BRAFRAF1KDRLCKJAK3 | |
| SCHEMBL1149152 | 0.84 | LCK (0.53) | BRAFRAF1KDRLCKJAK3 | |
| SCHEMBL1079171 | 0.84 | RAF1 (0.71) | BRAFRAF1KDRLCKJAK3 | |
| SCHEMBL1149293 | 0.84 | LCK (0.61) | BRAFRAF1KDRLCKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
| EP-2269993-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | H1-2, H1-3, H1-0 | BRAF 2498/4885RAF1 781/4885KDR 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.