Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.59 |
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.59 |
| ▸ | DHFR | P00374 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1009385 | 0.83 | TLR7 (0.54) | TLR8TLR7 | |
| SCHEMBL1008810 | 0.77 | TLR7 (0.46) | TLR8TLR7DHFR | |
| SCHEMBL1008581 | 0.77 | TLR7 (0.52) | TLR8TLR7 | |
| SCHEMBL1703456 | 0.77 | TLR7 (0.57) | TLR8TLR7 | |
| SCHEMBL1061481 | 0.76 | TLR8 (0.65) | TLR8TLR7 | |
| SCHEMBL1061503 | 0.76 | TLR8 (0.55) | TLR8TLR7 | |
| SCHEMBL16836321 | 0.76 | TLR8 (0.74) | TLR8TLR7 | |
| SCHEMBL1063827 | 0.76 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL1675437 | 0.75 | TLR8 (0.53) | TLR8TLR7 | |
| SCHEMBL1008843 | 0.75 | TLR8 (0.53) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268618-A1 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS | IRM LLC (BM) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009111337-A1 | COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS | IRM LLC (BM) | 2009-09-11 | — | — | WO | disclosed |