Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 15/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.44 |
| ▸ | FAP | Q12884 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291743 | 1.00 | DPP4 (0.46) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL9732206 | 0.98 | DPP4 (0.45) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL9732210 | 0.98 | DPP4 (0.45) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL10798391 | 0.97 | DPP4 (0.49) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL9731905 | 0.97 | DPP4 (0.49) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL10793158 | 0.97 | DPP4 (0.49) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL9731907 | 0.97 | DPP4 (0.49) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL8445420 | 0.83 | DPP4 (0.41) | DPP4DPP8DPP9DPP7FAP | |
| SCHEMBL15800753 | 0.82 | DPP4 (0.59) | DPP4CYP3A4 | |
| SCHEMBL13552351 | 0.82 | DPP4 (0.59) | DPP4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4684662-A | Disubstituted proline derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-08-04 | — | — | US | disclosed |
| EP-0115639-B1 | DISUBSTITUTED PROLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |
| EP-0115639-A1 | Disubstituted proline derivatives, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-08-15 | — | — | EP | disclosed |